Our Studies
Current studies
Mobilise-D is a 5-year, IMI-funded project that will produce validated and accepted digital mobility outcomes to monitor daily life gait of people with different mobility problems, with the goal to improve follow-up and personalized care.
PI: Prof Lynn Rochester
BAM Team Co-applicants: Prof Alison Yarnall, Dr Silvia Del Din
Funder: EU-IMI & EPFIA
BAM project members: Phil Brown, Dr Lisa Alcock, Heather Hunter, Cam Kirk, Laura Cordova Rivera
IDEA-FAST aims to identify digital endpoints that provide reliable, objective and sensitive evaluation of activities of daily life, disability and health related-quality of life for neurodegenerative diseases.
PI: Fai Ng
BAM Team Co-applicants: Prof Lynn Rochester, Prof Alison Yarnall, Dr Silvia Del Din
Funder: EU-IMI & EPFIA
BAM project members: Phil Brown, Heather Hunter, Dr Ellen Silva, Dr Chloe Hinchliffe
A pilot study to assess the safety, tolerability, feasibility and potential effectiveness of non-invasive vagus nerve stimulation in people with Parkinson’s.
PI: Prof Alison Yarnall
Funder: Dunhill Medical Trust & Parkinson’s UK
BAM project members: Dr Hilmar P Sigurdsson, Heather Hunter, Phil Brown
DELIRIUM-PD
A prospective study aimed at understanding the presentation, diagnosis and experience of delirium in inpatients with Parkinson's
PI: Dr Rachael Lawson
BAM Co-applicant: Prof Alison Yarnall
Funder: Parkinson’s UK
BAM project members: Florence Gerakios, Gemma Bate, Lauren Betteridge, Dr Rachel Cullinan, Dr Nicole Edwards
CiC - PD
Understanding medication adherence and its effect on motor function in people with Parkinson's
PI: Dr Silvia Del Din
BAM Co-applicants: Prof Lynn Rochester, Dr Lisa Alcock, Prof Alison Yarnall
Funder: MRC, EPSRC &NIHR
BAM project members: Emma Packer
Ghrelin in Dementia
To determine if ghrelin can be used as a biomarker for dementia and neurodegenerative disease
PI: Prof Alison Yarnall
Funder: Weston Brain Institute
BAM project members: Dr Ellen Silva
STRIDE
A double-blind, placebo-controlled, study to evaluate the efficacy and safety of 24 weeks treatment with REN001 in patients with Primary Mitochondrial Myopathy
PI: Prof Gráinne Gorman
Funder: Reneo Pharma
BAM project members: Phil Brown, Heather Hunter
SPIMD-301
A Phase 3 Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Daily Subcutaneous Injections of Elamipretide in Subjects with Primary Mitochondrial Disease Resulting from Pathogenic Nuclear DNA Mutations
PI: Prof Gráinne Gorman
Funder: Stealth BioTherapeutics Inc.
BAM project members: Phil Brown, Heather Hunter
TOPHAT
A clinical trial to explore the potential of ondansetron for treating hallucinations in people with Parkinson’s disease
PI: Prof Alison Yarnall
Funder: Parkinson's UK
Project members: Ann McNichol
COBALT
A trial to investigate the effect on overall health and functioning in patients with Lewy body dementia of memantine as an add-on treatment to a cholinesterase inhibitor
PI: Prof Alison Yarnall
Funder: MIHR HTA
Project members: Kathryn Walker
ActivDyad
Investigating the social and environmental contexts of habitual walking ACTIVities in older adult DYADs
PI: Dr Ríona Mc Ardle
Funder: The Art of Healthy Ageing Network, with the UKRI
BAM project members: Jenny Wales
Transforming the Objective Real-world measUrement of Symptoms (TORUS)
Directors: Prof Ian Craddock, Prof Lynn Rochester
Funder: EPSRC
BAM PIs: Dr Silvia Del Din, Prof Alison Yarnall
BAM Team members: Dr Lisa Alcock, Dr Kirsty Scott, Dr Chloe Hinchliffe
To determine if bile acid therapy can be used to manage mild cognitive impairment in Parkinson/s disease
PI: Prof Alison Yarnall
Funder: Intercept Pharmaceuticals
Project members: Kathryn Walker
ActivDem
Identifying modifiable psychosocial outcomes to maintain physical ACTIVity and promote independence in DEMentia
PI: Dr Ríona Mc Ardle
Funder: NIHR
BAM project members: Jenny Wales
Developing a dynamic FDG-PET/MR imaging methodology to study gait in Parkinson's
PI: Prof Lynn Rochester
BAM Co-applicant: Dr Lisa Alcock
Funder: Parkinson’s UK
BAM project members: Dr Hilmar P Sigurdsson, Phil Brown
MJFF Project
Measuring what matters – in whom it matters – ensuring diversity and equity in Parkinson’s disease research and care
PI: Prof Katie Brittain
Funder: Michael J Fox Foudation
BAM project members: Prof Lynn Rochester, Dr Ríona Mc Ardle, Megan Hanrahan, Jack Lumsdon
Ongoing studies
ICICLE-PD aims to better understand the mechanisms determining the transition from Parkinson’s disease to Parkinson's dementia in an incident cohort
CI: Prof David Burn
BAM Co-applicants: Prof Lynn Rochester,Prof Alison Yarnall
Funder: Parkinson’s UK
BAM project members: Dr Rachael Lawson
ICICLE-Gait
ICICLE-Gait aims to examine the utility of gait as a surrogate marker of cognitive decline in idiopathic Parkinson's disease
PI: Prof Lynn Rochester
Funder: Parkinson’s UK
BAM project members: Dr Lisa Alcock, Dr Silvia Del Din
GaitDem
What can Gait Analysis tell us about Dementia and its Subtypes? An Integrated Study of Brain and Behaviour
PI: Prof Lynn Rochester
Funder: Alzheimer’s Society
BAM project members: Dr Ríona Mc Ardle, Philip Brown, Dr Lisa Alcock
DETERMINE-PD
A pilot study to determine the prevalence of delirium in inpatients with Parkinson's
PI: Dr Rachael Lawson
Funder: Parkinson's UK
BAM project members: Prof Alison Yarnall
AIMM
Randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in patients with mitochondrial myopathy
PI: Prof Gráinne Gorman
Funder: MRC - Developmental Pathway Funding Stream(DPFS)
BAM project members: Dr Lisa Alcock, Prof Lynn Rochester, Heather Hunter, Phil Brown
NPS in LBD
Determining whether neuropsychiatric symptoms predict cognitive decline in Lewy body diseases, and their associations with brain networks
PI: Dr Rachael Lawson
Funder: Lewy body Society
BAM project members: Prof Alison Yarnall, Dr Laura Wright
FDG PET & Gait
Developing a dynamic FDG-PET/MR imaging methodology to study gait in ageing and neurodegenerative disease
PI: Prof Lynn Rochester
Funder: GE Healthcare
BAM project members: Dr Lisa Alcock, Dr Hilmar P Sigurdsson, Phil Brown
DELIRIUM-PD: Activity and Sleep
A prospective study using wearable sensors to identify activity and sleep patterns in inpatients with delirium and Parkinson’s disease
PI: Dr Rachael Lawson
Funder: DiMEN DTP
BAM project members: Prof Alison Yarnall, Dr Silvia Del Din, Gemma Bate
Collaborative work
Exenatide
A randomised, double blind, parallel group, placebo controlled, Phase 3 trial of Exenatide as a potential disease modifying treatment for Parkinson’s disease
PI: Prof Lynn Rochester
Funder: Cure Parkinson’s
BAM project members: Prof Alison Yarnall, Dr Silvia Del-Din
D&FP
PI: Prof Lynn Rochester
Funder: MRC
BAM project members: Dr Silvia Del-Din, Dr Javad Sarvestan
PPMI 2.0
A longitudinal, observational, multi-centre natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD) progression
PI: Prof Nicola Pavese
Funder: Michael J Fox Foundation
BAM project members: Prof Alison Yarnall
CREED
Cholinergic biomarkers of response to treatment in PD-MCI and LB-MCI
PI: Prof John-Paul Taylor
Funder: Lewy body Society
BAM project members: Prof Alison Yarnall, Dr Lisa Alcock
AWESSoM
A comprehensive and integrated research programme to help older people retain their independence for longer and push back the threshold of disability
PI: Professor Ngaire Kerse
Funders: University of Otago - Ageing Well National Science Challenge
BAM project members: Dr Silvia Del-Din, Dr Javad Sarvestan
DMFMOD1
A feasibility study to assess determining a muscle health index from wearable sensors validated with MRI metrics.
PI: Dr Annette Pantall
Funders: WT + RCR
BAM project members: Dr Lisa Alcock, Naveed E Saba
DMFMOD2
A study to develop a smart sock (MyoSock) with embedded sensors to monitor muscle health.
PI: Dr Annette Pantall
Funder: ESRC ISCF
BAM project members: Dr Lisa Alcock, Naveed E Saba
EPSRC Northern Health Futures Hub (NortHFutures) involves six regional universities, seven regional NHS Foundation Trust and 50+ partners, including regional, national, and global companies; health and care providers
BAM PI: Dr Silvia Del Din
Funder: EPSRC
Protocol advisors for gait assessment and data interpretation
Gait & balance outcomes in patients with SCA6
This study aims to better understand which changes to gait are caused by degeneration of the cerebellum (as seen in SCA6), and which are caused by other co- existing symptoms of mitochondrial disease
PI: Dr Yi Ng
Funders: Ataxia UK
BAM project members: Dr Lisa Alcock
COS-II
The COS2 clinical outcome study is evaluating a large group of dysferlinopathy patients to build upon and validate the findings of the first COS study.
PI: Professor Volker Straub
Funders: Jain Foundation
BAM project members: Dr Lisa Alcock
Ataxia in Mito
This study aims to measure and track cerebellar ataxia in patients with mitochondrial disease
PI: Dr Yi Ng
Funders: Academy of Medical Sciences
BAM project members: Dr Lisa Alcock
Data sharing statement
Data sharing on current and and completed projects may be available. If you are interested in sharing data, please contact the study PI.